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Panniculitis is uncommonly seen in both dogs and cats. Although a large number of organisms can cause infectious panniculitis, many of these are rarely seen in the UK. A variety of systemic diseases can also cause non-infectious panniculitis. Of the non-infectious cases, sterile nodular panniculitis is the most common type. Histopathology and deep tissue culture are indicated in most cases to reach a diagnosis. Infectious panniculitis must be treated with antimicrobial agents. Sterile nodular panniculitis usually responds well to glucocorticoid administration. This paper gives an overview of the different causes of panniculitis and how to approach suspected cases